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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
17.88
Human Site:
S619
Identified Species:
28.1
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
S619
V
S
A
S
R
N
M
S
I
I
D
A
F
K
S
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
S619
V
S
A
S
R
N
M
S
I
I
D
A
F
K
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
S619
T
S
T
S
R
N
M
S
I
I
D
A
F
K
S
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
S618
S
S
T
S
R
N
M
S
I
I
D
A
F
R
S
Rat
Rattus norvegicus
Q9JIM0
706
80103
S618
A
S
T
S
R
N
M
S
I
I
D
A
F
R
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
P618
S
K
A
S
V
S
T
P
T
K
N
M
S
I
M
Chicken
Gallus gallus
Q9IAM7
700
80005
K612
T
Y
K
S
V
P
D
K
N
S
S
I
M
D
A
Frog
Xenopus laevis
Q9W6K1
711
81112
I616
A
T
G
K
N
M
S
I
L
D
A
F
K
P
S
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
A530
E
A
I
I
R
A
K
A
H
R
D
R
G
E
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
D529
G
D
L
L
K
M
L
D
T
Q
G
L
K
V
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
S626
Y
M
P
P
Q
S
T
S
R
T
N
Y
A
S
G
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
L427
E
T
E
R
V
E
D
L
V
R
K
Y
F
S
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
I617
A
F
K
S
A
S
T
I
G
E
D
D
V
D
S
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
S604
K
K
K
I
P
A
F
S
D
S
T
V
I
S
D
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
A639
A
P
A
K
K
A
P
A
R
G
R
K
K
K
T
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
100
N.A.
86.6
N.A.
80
80
N.A.
13.3
6.6
6.6
13.3
N.A.
0
N.A.
6.6
6.6
P-Site Similarity:
100
100
N.A.
86.6
N.A.
86.6
86.6
N.A.
26.6
13.3
20
40
N.A.
13.3
N.A.
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
20
6.6
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
6.6
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
27
7
27
0
7
20
0
14
0
0
7
34
7
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
0
0
0
14
7
7
7
47
7
0
14
7
% D
% Glu:
14
0
7
0
0
7
0
0
0
7
0
0
0
7
7
% E
% Phe:
0
7
0
0
0
0
7
0
0
0
0
7
40
0
0
% F
% Gly:
7
0
7
0
0
0
0
0
7
7
7
0
7
0
7
% G
% His:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% H
% Ile:
0
0
7
14
0
0
0
14
34
34
0
7
7
7
0
% I
% Lys:
7
14
20
14
14
0
7
7
0
7
7
7
20
27
7
% K
% Leu:
0
0
7
7
0
0
7
7
7
0
0
7
0
0
0
% L
% Met:
0
7
0
0
0
14
34
0
0
0
0
7
7
0
7
% M
% Asn:
0
0
0
0
7
34
0
0
7
0
14
0
0
0
0
% N
% Pro:
0
7
7
7
7
7
7
7
0
0
0
0
0
7
0
% P
% Gln:
0
0
0
0
7
0
0
0
0
7
0
0
0
0
0
% Q
% Arg:
0
0
0
7
40
0
0
0
14
14
7
7
0
14
0
% R
% Ser:
14
34
0
54
0
20
7
47
0
14
7
0
7
20
47
% S
% Thr:
14
14
20
0
0
0
20
0
14
7
7
0
0
0
14
% T
% Val:
14
0
0
0
20
0
0
0
7
0
0
7
7
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
7
0
0
0
0
0
0
0
0
0
14
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _